Statistica 10 Rus Torrent

• user-friendly, fast and reliable statistical software • easy to learn • one edition includes all features • more than 220 statistical tests, procedures and graphs • reference software for • method comparison and method evaluation including Bland & Altman plot, Passing & Bablok, and Deming regression. • reference intervals • meta-analysis • see • free updates • available with an English, Chinese (simplified and traditional), French, German, Italian, Japanese, Korean, Polish, Portuguese (Brazilian), Russian and Spanish user-interface (help file and documentation in English) • compatible with all contemporary Windows desktop editions Licensing options.

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Pre-eclampsia (PE) is a complication of pregnancy that affects 5‑8% of women after 20 weeks of gestation. It is usually diagnosed based on the de novo onset of hypertension and proteinuria.

Preexisting hypertension in women developing PE, also known as superimposed PE on chronic hypertension (SPE), leads to elevated risk of maternal and fetal mortality. PE is associated with an altered microRNA (miRNA) expression pattern in the placenta, suggesting that miRNA deregulation is involved in the pathogenesis of PE.

Whether and how the miRNA expression pattern is changed in the SPE placenta remains unclear. The present study analyzed the placental miRNA expression profile in pregnancies complicated by SPE. MiRNA expression profiles in SPE and normal placentas were investigated using an Ion Torrent sequencing system.

Frutiger font free download. Sequencing data were processed using a comprehensive analysis pipeline for deep miRNA sequencing (CAP‑miRSeq). A total of 22 miRNAs were identified to be deregulated in placentas from patients with SPE. They included 16 miRNAs previously known to be associated with PE and 6 novel miRNAs. Among the 6 novel miRNAs, 4 were upregulated (miR‑518a, miR‑527, miR‑518e and miR‑4532) and 2 downregulated (miR‑98 and miR‑135b) in SPE placentas compared with controls. The present results suggest that SPE is associated with specific alterations in the placental miRNA expression pattern, which differ from alterations detected in PE placentas, and therefore, provide novel targets for further investigation of the molecular mechanisms underlying SPE pathogenesis.

Introduction Pre-eclampsia (PE) is a complication of pregnancy characterized by the onset of hypertension and proteinuria after 20 weeks of gestation. It affects 5–8% of pregnant women and is one of the predominant causes of maternal and neonatal mortality and morbidity worldwide (,). Women with chronic hypertension are 3–5 times more likely to develop PE than those with normal blood pressure (). Superimposed PE on chronic hypertension (SPE) is associated with poor pregnancy out comes (,). Despite the fact that the origin and pathogenesis of both PE and SPE have been extensively investigated (,,–), they remain unclear to date. Recent studies have reported the implication of microRNAs (miRNAs) in the development of PE (,).